WINSTON-SALEM, N.C. — Wake Forest has made huge gains under Dave Clawson, including tying a program record for wins and claiming an Atlantic Coast Conference division title last season.

The 21st-ranked Demon Deacons now have another shot at something they haven’t done: beating No. 5 Clemson. The teams meet Saturday, and the Demon Deacons are looking to end a 13-year losing streak in the series.

“The bottom line is we haven’t played well against them,” Clawson said. “So I just want to go out Saturday and I want our team to play at the level that we’re capable of.”

Wake Forest (3-0, 0-0 ACC) is the reigning Atlantic Division champion after replacing Clemson (3-0, 1-0), which had won six straight league titles before last year.

“They’re the Atlantic Division champs,” Clemson coach Dabo Swinney said. “And they know what that looks like it and they’re confident in that.”

But even last season, with Wake Forest winning 11 games and cracking the top 10 of the AP Top 25 poll, t he Tigers beat the Demon Deacons 48-27 at home in November. In fact, the Demon Deacons have lost by at least 14 points in all but one matchup, with the Tigers since last winning in 2008.

And this starts a critical two-game division stretch for the Tigers, who host No. 12 North Carolina State next week.

Here are things to know about Saturday’s Clemson-Wake Forest game:

BRESEE’S STATUS

Defensive tackle Bryan Bresee is expected to return to face No. 21 Wake Forest after missing last week’s win while being home with his family following the death of his 15-year-old sister, Ella, to brain cancer.

He returned to campus this on Monday, then flew back up Tuesday with coach Dabo Swinney and about 40 teammates and staffers for Ella’s funeral. Clemson has celebrated Ella’s life the past two weeks, including a moment of silence for her at Memorial Stadium last week and Swinney coaching in an “Ella Strong” T-shirt.

BOUNCING BACK?

The Demon Deacons needed to go to the final minute to hold off Liberty 37-36 last weekend at home. Afterward, Clawson sensed his team was so down by the close call that it needed a pick-me-up.

“I told these guys Sunday: We won the game,” Clawson said, adding: “We’re not going to walk around here with our head down all depressed after we win. Let’s fix the mistakes, know what we didn’t do well — but we won.”

HENRY’S DEACON PAST

Clemson starting defensive end K.J. Henry spent his youth rooting for Wake Forest, where his father, Keith, was a longtime assistant under Jim Grobe.

And the Winston-Salem-born Henry doesn’t let Swinney forget that it was a loss to Wake Forest in 2008 that led to the ouster of Tommy Bowden and Swinney getting the interim job.

“If my dad doesn’t beat him, he doesn’t get this job,” Henry joked.

QB PLAY

The quarterback matchup pairs Wake Forest’s Sam Hartman and Clemson’s D.J. Uiagalelei.

Hartman, who missed the opener while being treated for a blood clot, helped the Demon Deacons boast one of the nation’s top-scoring and most efficient offenses last season. He has thrown for seven touchdowns and two interceptions in his two appearances this year.

“They’re an RPO team and he knows how to read it and he’s very patient with his reads,” Clemson defensive co-coordinator Mickey Conn said. “So we’ve got to be patient with him.”

After a bumpy first season as the starter last year, Uiagalelei has thrown for five touchdowns with one interception.

“He looks better from last year, he looks more comfortable,” Wake Forest defensive lineman Rondell Bothroyd said.

SLIMMING DOWN

Clemson sophomore Payton Page made his first career start with starting defensive tackles Tyler Davis and Bryan Bresee out for the Louisiana Tech. It wouldn’t have happened without Page dropping some 80 pounds from his weight when he arrived on campus in 2021.

Page said he was up to 395 pounds after doing little else other than playing video games and ordering McDonald’s with his North Carolina high school’s season canceled due to the COVID-19 pandemic. He has a listed weight of 315 after sticking to the salad options.

“I feel like I’m moving much better,” he said.

No. 5 Clemson (3-0, 1-0 ACC) at No. 21 Wake Forest (3-0, 0-0), Saturday, noon ET (ABC)

Line: Clemson by 8 1/2, according to FanDuel Sportsbook.

Series record: Clemson leads 69-17-1.

WHAT’S AT STAKE?

The Tigers are starting a two-week stretch that could allow them to take complete control of the league’s Atlantic Division race, starting with a trip to face the reigning division champion Demon Deacons. Clemson, which hosts No. 12 North Carolina State next week, won six straight ACC titles before Wake Forest reached last year’s ACC championship game. The Demon Deacons, who are coming off a close home win against Liberty, have lost 13 straight to the Tigers.

KEY MATCHUP

Clemson’s defense against Wake Forest’s offense. The Demon Deacons had one of the best offenses in the Bowl Subdivision ranks last year and are third in the ACC in scoring (42.0) through three games. But the Tigers have held their first three opponents to a combined 42 points and an average of 312.7 yards per game.

PLAYERS TO WATCH

Clemson: RB Will Shipley. Shipley is averaging 83.0 yards rushing per game to go with six rushing scores. He ran for a career-best 139 yards with two scores in last week’s win against Louisiana Tech.

Wake Forest: QB Sam Hartman. He has thrown for 625 yards and seven touchdowns in his first two games since missing much of preseason camp and the season opener due to a blood clot.

FACTS & FIGURES

Wake Forest hasn’t beaten Clemson since a 12-7 win in October 2008, which led to the ouster of then-coach Tommy Bowden and the promotion of current Tigers coach Dabo Swinney as an interim choice. … The Demon Deacons have won 11 straight home games since falling to then-No. 1 Clemson to start the 2020 season. … The Tigers have lost one divisional game since October 2017, falling at N.C. State last year. … Clemson QB D.J. Uiagalelei has thrown for five touchdowns with one interception. … The Tigers are tied for 17th in FBS with just 38.3 penalty yards per game. … The Demon Deacons are tied for 10th in FBS with eight takeaways. … Clemson won last year’s meeting 48-27 at home.