CHARLOTTE, N.C. (AP) — Kyler Murray has never beaten the Carolina Panthers.

Then again, not many Arizona Cardinals quarterbacks have.

The Panthers have owned the series matchup against the Cardinals, winning 14 of 19 games, including six straight victories. They’ve defeated Arizona in each of the last three seasons — twice with Murray as the starting QB — and six straight times overall dating to 2015 by a whopping average margin of 35-17.

Two of those wins came in the playoffs, including the 2015 NFC championship game in which the Panthers destroyed the Cardinals 49-15 to reach their second Super Bowl.

“It means something,” defensive end Brian Burns said. “I would say from the history we have always had their number and always had it out for them.”

You have to go back to 2013 when Carson Palmer was playing quarterback for the Cardinals’ last win against the Panthers.

Of course, right now both teams are simply thinking about getting back to .500 after starting the season 1-2 when they meet Sunday at Bank of America Stadium.

Panthers coach Matt Rhule knows getting a win against Murray won’t be easy. Rhule called Murray one of the great quarterbacks in the league, citing his “magical” ability to extend plays as he did earlier this season in an overtime victory over Las Vegas.

Rhule also remembers facing Murray in college when the QB threw six touchdowns and ran for another score in Oklahoma’s 63-33 win over Rhule’s Baylor Bears.

“I saw him do things in college that made me just want to walk off the field,” Rhule said. “We sacked him and knocked the ball out of his hands, it bounced on the ground three times; he picked it up and threw it for an 18-yard first down. He’s one of the most amazing players I’ve ever seen.”

KYLER AT 50

Murray is still a young quarterback, but he’s far from a rookie.

Now in his fourth NFL season, he’ll play his 50th professional game Sunday.

“Fifty games? That’s a lot of games,” Murray said. “It doesn’t feel like it, honestly. That’s crazy.”

Murray was the No. 1 overall pick out of Oklahoma in 2019. He’s already a two-time Pro Bowl selection and helped lead the Cardinals to a playoff berth last season.

He said he has learned a lot over 50 games, but the biggest is simply perseverance.

“You’ve just got to keep going,” Murray said. “Control what you can control. Obviously, we’ve had a lot of ups and downs. But it’s a long season — one game doesn’t make or break you. The team knows that, the locker room knows that, so you can’t dwell on how we feel right now.”

WHERE’S THE BEEF?

The Cardinals are very thin at receiver right now with injuries to A.J. Green and Antoine Wesley.

They’re also very small.

After Green left last Sunday’s game against the Rams with a knee injury, the Cardinals were left with the 5-foot-7 Greg Dortch and the 5-foot-9 Andy Isabella and Marquise Brown.

Arizona coach Kliff Kingsbury hopes Rondale Moore can return this week, which will help. But Moore is also just 5-7, so that doesn’t help the height problem.

“We’ve just got to be smart about how we maximize those guys and utilize them, take advantage of what they do well,” Kingsbury said.

Three-time All-Pro DeAndre Hopkins is also out while he misses the fourth game of a six-game suspension for breaking the NFL’s rules on performance-enhancing drugs.

JUST GET OPEN

This season has been a struggle so far for Panthers quarterback Baker Mayfield, who has the second-lowest completion in the league and is 25th overall in QB rating.

Rhule has refused to place all of the blame on his new quarterback, challenging the team’s wide receivers to do a better job of getting separation from defenders.

“Get open and the ball will come your way,” Rhule said.

Rhule added of Mayfield: “I think Baker’s going to be play great this week. He’s focused. He’s prepared.”

PINEIRO’S POP

There was a bit of panic from the Panthers when kicker Zane Gonzalez was lost for the year with a groin injury in the preseason.

But replacement Eddy Pineiro, who lost a training camp competition to Greg Zuerlein with the Jets, has been up to the task. He’s 7 of 7 on field goal attempts and is perfect on extra points, too.

TAKING IT AWAY

The Panthers failed to register a takeaway in their first two games, but they turned things around last week against the Saints with three takeaways to get back to even on the season in the turnover differential.

Carolina blitzed more against Jameis Winston and they’re expected to use that same strategy to get Murray off his mark Sunday.

ARIZONA (1-2) at CAROLINA (1-2)

Sunday, 4:05 p.m. EDT, Fox

OPENING LINE: Panthers by 1 1/2, according to FanDuel SportsBook.

AGAINST THE SPREAD: Cardinals 1-2, Carolina 1-2.

SERIES RECORD: Panthers lead 14-5.

LAST MEETING: Panthers beat Cardinals 34-10 at Nov. 14, 2021, in Arizona.

LAST WEEK: Cardinals lost 20-12 to the Rams; Panthers beat Saints 22-14.

CARDINALS OFFENSE: OVERALL (15), RUSH (17), PASS (12), SCORING (t-13).

CARDINAL DEFENSE: OVERALL (23), RUSH (t-11), PASS (30), SCORING (31).

PANTHERS OFFENSE: OVERALL (30), RUSH (14), PASS (31), SCORING (t-13).

PANTHERS DEFENSE: OVERALL (18), RUSH (22), PASS (13), SCORING (t-12).

TURNOVER DIFFERENTIAL: Cardinals plus-2; Panthers even.

CARDINALS PLAYER TO WATCH: QB Kyler Murray had some good moments Sunday against the Rams, finishing 37 of 58 passing for 314 yards, but the Cardinals still couldn’t find the end zone and settled for four Matt Prater field goals. Murray seems to be getting on the same page with WR Marquise Brown, his college teammate at Oklahoma, as the duo connected 14 times for 140 yards.

PANTHERS PLAYER TO WATCH: RB Christian McCaffrey is hitting his stride with back-to-back 100-yard rushing games for the Panthers. After being held to 32 yards in the season opener, the 2019 All-Pro is now tied for fifth in the league in rushing with 243 yards and looking explosive, particularly when he gets in the open field.

KEY MATCHUP: Panthers QB Baker Mayfield vs. Cardinals secondary. Mayfield is off to a slow start and ranks 25th in the league in quarterback rating with only three TD passes in three games. The Panthers’ passing game is 31st in the league, and the team’s third down passing game has been poor. But Mayfield has a chance to get on track this week against the Cardinals, who are 30th in the league against the pass.

KEY INJURIES: Cardinals WR A.J. Green will be out indefinitely with a knee injury, while WR DeAndre Hopkins remains suspended for three more games. WRs Rondale Moore and Antoine Wesley are also dealing with injuries, leaving a stable of mostly smaller receivers such as Brown, Greg Dortch, Andre Baccellia and Andy Isabella, along with tight end Zach Ertz. Cardinals DL Rashard Lawrence had surgery on his hand and won’t play this week … Carolina enters the game relatively healthy.

SERIES NOTES: The Panthers have owned the Cardinals through the years, winning 14 of 19 matchups overall, including the past six. Carolina has beaten Arizona in each of the past three seasons. Over the past six matchups, the Panthers haven’t scored fewer than 27 points.

STATS AND STUFF: Arizona has been outscored 56-13 in the first half of games this season. … QB Kyler Murray is 2-0 in his career in head-to-head starts against Baker Mayfield. … After scoring 18 touchdowns last season, Cardinals RB James Conner has had a slow start to the season with just 90 yards rushing. That’s largely due to the Cardinals falling behind in games and having to throw the ball to catch up. However, Conner has nine TDs in his past nine road games with Arizona, accumulating at least 50 yards from scrimmage in all of those games. … Cardinals DE J.J. Watt could pose major problems for Panthers rookie LT Ickey Ekwonu, who struggled against elite pass rusher Myles Garrett in Week 1. … The Panthers snapped a seven-game losing streak at home last week — and a nine-game skid overall — with a win over the Saints. … Carolina’s defense had three takeaways against the Saints after getting none the first two weeks. … In his first game with the Panthers, WR Laviska Shenault had two catches for 90 yards, including a 67-yard catch and run for a touchdown, sparking a win against New Orleans.

FANTASY TIP: WR D.J. Moore, who has had at least 1,150 yards receiving in each of the past three seasons, has just seven catches for 88 yards this season and one touchdown. He had great chemistry with Mayfield in training camp, and the thinking is he’s going to have a breakout game soon.